Small animal look-locker inversion recovery (SALLI)
نویسندگان
چکیده
Introduction and purpose Cardiac T1 mapping allows for quantitative analysis of myocardial tissue properties. Pulse sequences for human applications are not suitable for in-vivo studies in small animals.The aim of this study was to develop a single magnetic resonance imaging (MRI) approach for comprehensive assessment of cardiac function and tissue properties in small animals with high heart rates.
منابع مشابه
Validation of Small-Animal Look-Locker Inversion Recovery (SALLI) Cine versus Cine MR in assessment of left ventricular function
Background Small-Animal Look-Locker Inversion Recovery (SALLI) is a novel imaging method that generates simultaneously cardiac T1 maps, cine MR and inversion recovery-prepared images for high heart rates. T1 mapping by SALLI has been tested and compared with histology, however the assessment of left ventricular (LV) function has not yet been validated. Our aim was to compare the measurement of ...
متن کاملAssessment of cardiac function and myocardial morphology using small animal Look-Locker inversion recovery (SALLI) MRI in rats.
Small animal magnetic resonance imaging is an important tool to study cardiac function and changes in myocardial tissue. The high heart rates of small animals (200 to 600 beats/min) have previously limited the role of CMR imaging. Small animal Look-Locker inversion recovery (SALLI) is a T1 mapping sequence for small animals to overcome this problem. T1 maps provide quantitative information abou...
متن کاملAssessment of Diffuse Myocardial Fibrosis in Rats Using Small Animal Look-Locker Inversion Recovery (SALLI) T1 Mapping
Background It has been shown that the concentration of gadopentetate dimeglumine (GdDTPA) in myocardium and blood can be assessed from T1 measurements, and be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small animal model could be quantitatively assessed by measuring myocardial ECV using small animal Look-Locker inver...
متن کاملRespiratory motion navigated Look-Locker imaging for small animal myocardial T1mapping
Background The quantification of T1 relaxation time has become an important indicator for diffuse cardiomyopathies. In small animal studies, such as mouse and rat, fast heart beats and respiratory rates are major obstacles to use clinical T1 mapping methods. For small animal T1 mapping, SALLI (Messroghli DR et al., 2011) and mCINE-IR(Smit H et al., 2014) had been reported using the Look-Locker ...
متن کاملRapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.
Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T(1) mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal ...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2011